Native Chemical Ligation: Ultrafast Synthesis of Block Copolymers

Native chemical ligation (NCL) allows the synthesis of proteins and peptides with excellent efficiency, starting from a mixture unprotected short peptide fragments. The chemo- regioselectivity NCL provide access to functional biomacromolecules such as without protection–deprotection strategies under mild conditions. In contrast, less progress has been made in non-natural polymer conjugation. Metal contamination, synthetic difficulties, laborious purifications, or lack group tolerance limits complex design. Here, we have studied potential for Diblock ABA triblock copolymers were synthesized via high efficiency within 1 h at room temperature. An A-alt-B block copolymer was also remarkable degree polymerization bifunctional thioester cysteine end polymers. size exclusion chromatography NMR spectroscopy analyses polymers confirmed structure